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While they may appear interchangeable, the correct choice depends on how the medication will be used, how often it will be accessed, and the sensitivity of the tissue or patient involved
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L-Citrulline may actually be more effective at boosting L-Arginine levels due to the poor bioavailability of L-Arginine
But the jump from C57BL/6 mice to humans involves differences in metabolic rate, NNMT tissue distribution, adipose tissue physiology, and drug metabolism that preclinical data cannot address
doi: 10.1208/s12248-013-9465-7